Rapid Access to Bi‐ and Tri‐Functionalized Dibenzofurans and their Application in Selective Suzuki–Miyaura Cross Coupling Reactions
作者： Caroline Wern , Christian Ehrenreich , Dominik Joosten , Thorsten vom Stein , Herwig Buchholz
关键词: Chemistry 、 Rapid access 、 Combinatorial chemistry 、 Trifluoromethanesulfonate 、 Dibenzofuran 、 Bromine 、 Coupling reaction 、 Moiety 、 Regioselectivity 、 Chemoselectivity
摘要: Syntheses of 1,2-, 1,3-, 1,4-, 1,8-, 2,4-, 3,4-, 4,8-, 1,2,4-, 1,2,8- and 1,3,4-functionalized dibenzofurans in few steps with good to excellent yields starting from dibenzofuran-1-ol or -4-ol are presented. These rapidly accessible bi- tri-functionalized building blocks great interest for the synthesis bioactive substances functional material development. Furthermore, intermediates containing both a bromine triflate moiety, selective monosubstitution by means Suzuki-Miyaura reaction (SMR) is described.
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