Neutralizing IL-17 prevents obliterative bronchiolitis in murine orthotopic lung transplantation.

摘要: Obliterative bronchiolitis (OB) is the key impediment to long-term survival of lung transplant recipients and lack a robust preclinical model precludes examining OB immunopathogenesis. In current study, lungs from C57BL/10 H-2(b) mice that are MHC compatible, but minor histocompatability antigen incompatible, were transplanted into C57BL/6 mice. Histological features cytokine profiles assessed. Moderate rejection (grade A3) developed by day 14, with evidence at time point. At 21 days, was present in 55% grafts moderate severe A3-A4) all 28 44% A4) all. IL-17A, not IL-17F, splenic mRNA transcripts serum protein levels increased only OB, whereas IL-10 non-OB Neutralizing IL-17 prevented down regulated acute rejection, upregulated systemic IL-10. Collectively, these data show transplantation histoincompatible results highly reproducible OB. addition, indicate neutralizing IL-17A or augmenting could be therapeutic interventions prevent