Polymorphisms in adipokine-related genes to predict treatment outcomes in patients (pts) with metastatic colorectal cancer (mCRC) treated with bevacizumab-based chemotherapy.

摘要: 600Background: The molecular effects of obesity are mediated by alterations in the levels adipokines, which produced mainly adipose tissue. Adipokines have multiple effects, including insulin sensitivity, cell proliferation, inflammation, and angiogenesis. We previously reported that single-nucleotide polymorphisms (SNPs) obesity-related genes were associated with recurrence probability CRC treated 5-FU based adjuvant chemotherapy. This study aimed to evaluate whether SNPs adipokine-related may predict clinical outcomes bevacizumab mCRC pts. Methods: Genomic DNA was obtained from pts receiving plus FOLFIRI as first-line treatment analyzed using PCR-based direct sequencing. Eleven functional 7 (LEP, LEPR, ADIPOQ, ADIPOR1, RETN, TNFa NAMPT) tested 291 FIRE3 trial cohort (NCT00433927). Main characteristics following: male/female = 193/98; median age 65; High BMI (BMI ≥ 25 Kg/m2)/lo...