Impact of STAT5 on Normal Tissue Development and Cancer

摘要: STAT5A and STAT5B are two closely related transcription factors that transduce signals from cytokines growth factors. Two tissues rely upon STAT5 for lineage commitment differentiation the mammary gland haematopoietic system. During pregnancy, epithelial cells undergo extensive proliferation to generate milk-producing alveolar structures. Alveologenesis is abrogated in absence of both B fat pad transplantation experiments demonstrated while ability stem ductal outgrowths was not affected by loss STAT5A/B, compartment failed develop pregnant mice. In contrast, system, control progenitor cell fate essential development immune T, NK lineages. Aberrant activity has major consequences can induce tumours blood breast, addition other tissues. The mechanisms constitutive manifold include mutation upstream kinase JAK2.