Do hereditary syndrome-related gynecologic cancers have any specific features?

摘要: Hereditary syndromes are responsible for 10 % of gynaecologic cancers, among which hereditary breast-ovarian cancer and non-polyposis colon syndromes, known as HBOC Lynch respectively, present the highest relative risk. The latter predisposes to endometrial both contribute ovarian cancer. Cowden syndrome-related increased risk ovarian, uterine cervical cancers associated with Peutz-Jeghers syndrome, also demonstrated, while Li-Fraumeni syndrome patients prone develop cancers. Despite these syndromes’ susceptibility being consensual, it is still not clear whether tumours have any epidemiologic, clinical, pathologic or imaging specific features that could allow intervening physicians raise suspicion a in without genetic Moreover, controversy exists regarding screening surveillance schemes. Our literature review provides an updated perspective on evidence-based related each well most accepted guidelines. In addition, some illustrative cases presented. • mainly HGSC, arises fallopian fimbriae. LS-related show histological diversity predilection lower segment. LS CS-related mostly non-serous type, usually endometrioid. Ovarian SCTAT adenoma malignum strongly PJS. Unfortunately, do seem distinctive features.