Microcystin-LR affects properties of human epidermal skin cells crucial for regenerative processes
作者： Marcin Kozdęba , Julia Borowczyk , Eliza Zimoląg , Marcin Wasylewski , Dariusz Dziga
DOI: 10.1016/J.TOXICON.2014.01.003
关键词: Actin cytoskeleton 、 Toxicity 、 Keratinocyte migration 、 Biology 、 Human skin 、 Regeneration (biology) 、 Cytoskeleton 、 Cell biology 、 Actin cytoskeleton organization 、 Immunology 、 Cell migration
摘要: The occurrence of cyanobacterial toxic peptides, including microcystins (MCs), is an emerging health issue due to the eutrophication water bodies. MCs have a strong influence on human cells, predominantly hepatocytes, however, toxicity was also observed in kidney, lung and dermal skin cells. Skin as most external barrier body responsible for maintenance homeostasis whole organism. Simultaneously, cells may be exposed during recreational activity. aim this study examine impact MC-LR processes indispensable normal function regeneration, namely, viability, migration actin cytoskeleton organization keratinocytes. results showed that short exposure does not affect proliferation keratinocytes but it after longer incubation dose-dependent manner. Total disruption under same concentration. Furthermore, keratinocyte inhibited at concentrations 50 μM only 4 h. Some negative impacts examined cell partly reversible. effects, regarding possible high exposition toxins MCs, are severe cause diverse problems.
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