Analgesic efficacy of low-dose diclofenac versus paracetamol and placebo in postoperative dental pain.

摘要: Aims: To compare the efficacy and safety of diclofenac-K (12.5 mg) vs paracetamol (500 placebo given in a flexible dosage regimen to treat pain resulting from extraction impacted third molar teeth. Methods: This was 2-day, double-blind, double- dummy, randomized, parallel-group, placebo-controlled study tablets patients with moderate or severe within 8 hours molars. Results: After first 2-tablet dose, took on average 2.5 additional 2.4 paracetamol, almost all as 1- tablet doses. Most discontinued by taking rescue medication (ibuprofen 200 day. Pain relief after initial dose (2 x 12.5 superior (P < .01 for outcomes) comparable 500 mg). About 30% each active treatment group during study, compared 78% placebo. 70% considered overall be "some," "a lot," "complete" only 15% The incidence adverse events low between treatments. Conclusion: An double-dose adequately relieved most intense postoperative pain, multiple (1 2 tablets) maintained adequate thereafter. needed 1-tablet doses following dose.