Surgical skin markers impair human saphenous vein graft smooth muscle and endothelial function.

摘要: Over one million coronary artery bypass grafts (CABG) and peripheral revascularization procedures are performed each year. Despite the higher patency rate of internal mammary when compared with human saphenous vein (HSV) increased interest in other arterial conduits, HSV remains most widely used conduit for CABG procedures. Vein graft failure high, however, approaching 40 per cent at 18 months postoperatively.1 The predominant histological finding failed is intimal hyperplasia, which thought to be manifestation cellular responses injury.2 injury during intraoperative preparation leads accelerated atherosclerosis, subsequent failure.2, 3 Injurious mechanisms include endovascular harvesting techniques, radial distension, choice storage solution.1, 4, 5 Optimal before surgical anastomosis hence important long-term patency.6 Vein marking a practice frequently properly orient implantation. Originally intended use skin area around sites, markers sterile, inexpensive, readily available surgeons marking. The chemical constituents these consist alcohol-based solvents dyes methylene blue or gentian violet. impairs both endothelium-dependent endothelium-independent function.7 Similarly, violet decrease relaxation sodium nitroprusside.8 Although deleterious effects well established, using still accepted vascular nontoxic dermatology applications, little known about applying marker directly grafts. This study examined on functional viability autologous