Method for making activated neutrophils recognizable to macrophages

作者: Richard D. Cummings , Moon-Jae Cho

DOI:

关键词: ApoptosisBiologyCell biologyInflammatory response

摘要: Methods for treating and modulating an inflammatory response using compositions containing a primarily monomeric or dimeric form of galectin-1. The stimulates apoptosis activated neutrophils while the inhibits neutrophils. screening compounds which have galectin-1-like functions are also identified.

参考文章(9)
CH Homburg, M de Haas, AE von dem Borne, AJ Verhoeven, CP Reutelingsperger, D Roos, Human neutrophils lose their surface Fc gamma RIII and acquire Annexin V binding sites during apoptosis in vitro Blood. ,vol. 85, pp. 532- 540 ,(1995) , 10.1182/BLOOD.V85.2.532.532
Moonjae Cho, Richard D. Cummings, Galectin-1, a β-Galactoside-binding Lectin in Chinese Hamster Ovary Cells Journal of Biological Chemistry. ,vol. 270, pp. 5198- 5206 ,(1995) , 10.1074/JBC.270.10.5198
Linda G. Baum, Jeffrey J. Seilhamer, Mabel Pang, Wendy B. Levine, Dor� Beynon, Judith A. Berliner, Synthesis of an endogeneous lectin, galectin-1, by human endothelial cells is up-regulated by endothelial cell activation. Glycoconjugate Journal. ,vol. 12, pp. 63- 68 ,(1995) , 10.1007/BF00731870
Nancy L. Perillo, Karen E. Pace, Jeffrey J. Seilhamer, Linda G. Baum, Apoptosis of T cells mediated by galectin-1 Nature. ,vol. 378, pp. 736- 739 ,(1995) , 10.1038/378736A0
AV Timoshenko, SN Cherenkevich, HJ Gabius, Viscum album agglutinin-induced aggregation of blood cells and the lectin effects on neutrophil function. Biomedicine & Pharmacotherapy. ,vol. 49, pp. 153- 158 ,(1995) , 10.1016/0753-3322(96)82609-6
Moonjae Cho, Richard D. Cummings, CHARACTERIZATION OF MONOMERIC FORMS OF GALECTIN-1 GENERATED BY SITE-DIRECTED MUTAGENESIS Biochemistry. ,vol. 35, pp. 13081- 13088 ,(1996) , 10.1021/BI961181D
N. L. Perillo, Madeline E. Marcus, Linda G. Baum, Galectins: versatile modulators of cell adhesion, cell proliferation, and cell death Journal of Molecular Medicine. ,vol. 76, pp. 402- 412 ,(1998) , 10.1007/S001090050232
Glenn E. Nedwin, Timothy S. Bringman, Pierre-Olivier Couraud, 14-Beta-gal mammalian lectins ,(1989)
How sweet it is: selectin-mediating drugs. Nature Biotechnology. ,vol. 10, pp. 383- 389 ,(1992) , 10.1038/NBT0492-383