Proteinase-Activated Receptors (PARs) and Calcium Signaling in Cancer
作者： Roland Kaufmann , Morley D. Hollenberg
DOI: 10.1007/978-94-007-2888-2_45
关键词: Cell biology 、 Protease-activated receptor 、 Carcinogenesis 、 Chemistry 、 Intracellular 、 Receptor 、 Second messenger system 、 Calcium in biology 、 Calcium signaling 、 Signal transduction
摘要: Proteinase activated receptors (PARs), a small subfamily of G protein-coupled with four members, PAR1, PAR2, PAR3 and PAR4, are expressed in various tumours from epithelial origin can play an important role tumour progression metastasis. Within the complex intracellular PAR signaling networks triggered by PARs, elevation free calcium ion concentrations represents key second messenger system. In this review, we summarize current information about mechanisms whereby PARs signal via setting cancer discuss possibilities for using PAR-[Ca2+]i pathway as target therapy cancer.
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