Synthesis of polyfunctional 2-thionicotinonitriles
作者： I. N. Bardasov , D. L. Mikhailov , M. Yu. Belikov , A. Yu. Alekseeva , O. V. Ershov
DOI: 10.1134/S1070428016110087
关键词: Sulfur 、 Chemistry 、 Organic chemistry 、 Sodium hydrosulfide 、 Benzonitrile
摘要: Reaction of 2-amino-4-arylbuta-1,3-diene-1,1,3-tricarbonitriles with sulfur in benzonitrile affords 4-amino-6-aryl-2-thio-1,2-dihydropyridine-3,5-dicarbonitriles. They also are synthesized by an authentic synthesis from 4-amino-6-aryl-2-bromopyridine-3,5-dicarbonitriles and sodium hydrosulfide.
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sci-hub.se 参考文章(19)
Ivan N. Bardasov, Anastasiya U. Alekseeva, Oleg V. Ershov, Mikhail Yu. Belikov, Four component DHARMA-synthesis of some densely functionalized 1,8-naphthyridines Tetrahedron Letters. ,vol. 56, pp. 5434- 5436 ,(2015) , 10.1016/J.TETLET.2015.08.013
Homayon J. Arabshahi, Michelle van Rensburg, Lisa I. Pilkington, Chae Yeon Jeon, Mirae Song, Ling-Mey Gridel, Euphemia Leung, David Barker, Milena Vuica-Ross, Konstantin P. Volcho, Alexandra L. Zakharenko, Olga I. Lavrik, Jóhannes Reynisson, A synthesis, in silico, in vitro and in vivo study of thieno[2,3-b]pyridine anticancer analogues MedChemComm. ,vol. 6, pp. 1987- 1997 ,(2015) , 10.1039/C5MD00245A
Monika Szabo, Tracey Huynh, Celine Valant, J. Robert Lane, Patrick M. Sexton, Arthur Christopoulos, Ben Capuano, A structure–activity relationship study of the positive allosteric modulator LY2033298 at the M4 muscarinic acetylcholine receptor MedChemComm. ,vol. 6, pp. 1998- 2003 ,(2015) , 10.1039/C5MD00334B
Ebtehal S. Al-Abdullah, Synthesis and anticancer activity of some novel tetralin-6-yl-pyrazoline, 2-thioxopyrimidine, 2-oxopyridine, 2-thioxo-pyridine and 2-iminopyridine derivatives. Molecules. ,vol. 16, pp. 3410- 3419 ,(2011) , 10.3390/MOLECULES16043410
Victor P Litvinov, The chemistry of 3-cyanopyridine-2(1H)-chalcogenones Russian Chemical Reviews. ,vol. 75, pp. 577- 599 ,(2006) , 10.1070/RC2006V075N07ABEH003619
A. Yu. Alekseeva, D. L. Mikhailov, I. N. Bardasov, O. V. Ershov, O. E. Nasakin, A. N. Lyshchikov, Heterocyclization of michael adducts of β-diketones with arylmethylidene derivatives of malononitrile dimers Russian Journal of Organic Chemistry. ,vol. 50, pp. 244- 250 ,(2014) , 10.1134/S1070428014020171
A. Yu. Alekseeva, D. L. Mikhailov, I. N. Bardasov, O. V. Ershov, O. E. Nasakin, One-stage synthesis of highly functionalized N-substituted 1,8-naphthyridines Russian Journal of Organic Chemistry. ,vol. 49, pp. 1715- 1717 ,(2013) , 10.1134/S1070428013110286
Victor P Litvinov, Cyanoacetamides and their thio- and selenocarbonyl analogues as promising reagents for fine organic synthesis Russian Chemical Reviews. ,vol. 68, pp. 737- 763 ,(1999) , 10.1070/RC1999V068N09ABEH000533
Mohamed M. Abdulla, Synthesis and Reactions of Some Substituted Heterocyclic Systems as Anti-arrhythmic Agents Monatshefte für Chemie - Chemical Monthly. ,vol. 139, pp. 69- 76 ,(2008) , 10.1007/S00706-007-0739-6
Ivan N. Bardasov, Anastasiya U. Alekseeva, Denis L. Mihailov, Oleg V. Ershov, Dmitry A. Grishanov, Double heteroannulation reactions of 1-naphthol with alkyl- and arylmethylidene derivatives of malononitrile dimer Tetrahedron Letters. ,vol. 56, pp. 1830- 1832 ,(2015) , 10.1016/J.TETLET.2015.02.081