Finasteride in the treatment of Japanese men with male pattern hair loss

摘要: Finasteride is a type 2 5 alpha-reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone, key mediator male pattern hair loss (androgenetic alopecia). The objective this study was identify the optimal dosage finasteride and evaluate its efficacy safety in treatment Japanese men with loss. In double- blind randomized study, 414 received 1 mg (n = 139), 0.2 137), or placebo 38) once daily for 48 weeks. Efficacy evaluated by global photographic assessment, patient self-assessment, investigator assessment. All endpoints showed significant improvement therapy 12 weeks (p < 0.05 versus placebo). At weeks, 58%, 54%, 6% mg, groups, respectively, had improved based on assessments photographs. were numerically superior dose over at generally well tolerated. mg\day slows improves growth