Insulin-Like Activity of Taurine

作者: Joseph Maturo , Elliott C. Kulakowski

DOI: 10.1007/978-1-4899-0405-8_23

关键词: GlycogenesisTaurineSerum insulinSkeletal muscleInternal medicineInsulinEndocrinologyGlycolysisCarbohydrate metabolismInsulin receptorChemistry

摘要: There is now an increasing body of data that taurine (2-aminoethanesulfonic acid) at pharmacological concentrations alters carbohydrate metabolism. Early reports from Ackerman and Heinsen (1) Macallum Sivertz (10) found was potent a hypoglycemic agent. Several teams investigators have confirmed these initial results. Donadio Fromageot (4) the properties presented evidence increased glucose utilization in rat diaphragm. Lampson et al. (9) reported capable enhancing effects insulin on cardiac glycolysis, glycogenesis oxygen consumption. Moreover, when fasting rats were given bolus injection glucose, Kulakowski Maturo (6) observed alone reducing serum levels while stimulating 3-0-methylglucose uptake skeletal muscle liver, liver. This occurred without concomitant increase levels.

参考文章(16)
D Reibel, Changes in taurine content in heart and other organs of diabetic rats Journal of Molecular and Cellular Cardiology. ,vol. 11, pp. 827- 830 ,(1979) , 10.1016/0022-2828(79)90407-3
Tokunaga Hisashi, Yoneda Yukio, Kuriyama Kinya, Protective actions of taurine against streptozotocin-induced hyperglycemia. Biochemical Pharmacology. ,vol. 28, pp. 2807- 2811 ,(1979) , 10.1016/0006-2952(79)90566-5
Peter Rieser, Insulin, Substrate Transport, and Protein Synthesis in Muscle Archives of Internal Medicine. ,vol. 123, pp. 267- 271 ,(1969) , 10.1001/ARCHINTE.1969.00300130049008
Joseph M. Maturo, Morley D. Hollenberg, Linda S. Aglio, Insulin receptor: insulin-modulated interconversion between distinct molecular forms involving disulfide-sulfhydryl exchange. Biochemistry. ,vol. 22, pp. 2579- 2586 ,(1983) , 10.1021/BI00279A040
W. G. Lampson, J. H. Kramer, S. W. Schaffer, Potentiation of the actions of insulin by taurine. Canadian Journal of Physiology and Pharmacology. ,vol. 61, pp. 457- 463 ,(1983) , 10.1139/Y83-070
J.M. Maturo, G. Siegel, C. Furino, Studies on the effect of 2-hydroxy-5-nitrobenzyl bromide on the mechanism of insulin. Life Sciences. ,vol. 16, pp. 415- 422 ,(1975) , 10.1016/0024-3205(75)90262-3
Elliott C. Kulakowski, Joseph Maturo, Hypoglycemic properties of taurine: not mediated by enhanced insulin release. Biochemical Pharmacology. ,vol. 33, pp. 2835- 2838 ,(1984) , 10.1016/0006-2952(84)90204-1
P. Cuatrecasas, Isolation of the Insulin Receptor of Liver and Fat-Cell Membranes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 69, pp. 318- 322 ,(1972) , 10.1073/PNAS.69.2.318
Kazuo NAKAGAWA, Kinya KURIYAMA, Effect of taurine on alteration in adrenal functions induced by stress. Japanese Journal of Pharmacology. ,vol. 25, pp. 737- 746 ,(1975) , 10.1254/JJP.25.737
Elliott C. Kulakowski, Joseph Maturo, Stephen W. Schaffer, The identification of taurine receptors from rat heart sarcolemma Biochemical and Biophysical Research Communications. ,vol. 80, pp. 936- 941 ,(1978) , 10.1016/0006-291X(78)91335-9