The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genes.
作者： Galya Vassileva , Hortensia Soto , Albert Zlotnik , Hideki Nakano , Terutaka Kakiuchi
关键词: Spleen 、 Lymph 、 Chemokine 、 Lymph node 、 Regulation of gene expression 、 T cell 、 Biology 、 White pulp 、 Lymphatic system 、 Molecular biology
摘要: 6Ckine is an unusual chemokine capable of attracting naive T lymphocytes in vitro. It has been recently reported that lack expression lymphoid organs a prominent characteristic mice homozygous for the paucity lymph node cell (plt) mutation. These show reduced numbers cells nodes, Peyer's patches, and white pulp spleen. The genetic reason plt mouse, however, remained unknown. Here we demonstrate mouse encoded by two genes, one which expressed deleted mice. A second gene intact mouse.
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