Cytochrome P450 2D6 polymorphism and drug utilization in patients with oral lichen planus.
作者： Vladimíra Paulusová , Christiane Rösch , Ivo Dřízhal , František Perlík , Vladimír Mašín
DOI: 10.3109/00016351003636382
关键词: CYP2D6 、 Oral lichen planus 、 Gastroenterology 、 Population study 、 Drug metabolism 、 Internal medicine 、 Restriction fragment length polymorphism 、 Pharmacology 、 Drug Utilization 、 Biology 、 Oral mucosa 、 Genotype
摘要: AbstractObjective. Oral lichen planus (OLP) is one of the commonest diseases oral mucosa. The etiology disease unknown. Our goal was to determine frequencies functionally important alleles which metabolic rate (phenotype) individuals with OLP and compare drug utilization, focus on CYP2D6, that a control group. Material methods. study population consisted 46 patients OLP, 60 sex- age-matched subjects for utilization evaluation 223 healthy non-medicated controls genotype comparison. DNA analysis done using polymerase chain reaction restriction fragment length polymorphism. gene CYP2D6 analyzed CYP2D6*3,*4,*5,*6 duplication. Drug evaluated according Anatomical Therapeutic Chemical code, liver metabolism pathway mono- or polytherapy. Results. Intake drugs significantly higher in group comparison subjects. T...
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