Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol

摘要: The prototypical xanthine oxidase (XO) inhibitor allopurinol, has been the cornerstone of clinical management gout and conditions associated with hyperuricemia for several decades. More recent data indicate that XO also plays an important role in various forms ischemic other types tissue vascular injuries, inflammatory diseases, chronic heart failure. Allopurinol its active metabolite oxypurinol showed considerable promise treatment these both experimental animals small-scale human trials. Although some beneficial effects compounds may be unrelated to inhibition XO, encouraging findings rekindled significant interest development additional, novel series inhibitors therapeutic indications. Here we present a critical overview pathophysiological review emerging strategies offered by this approach.