The CD95/CD95L signaling pathway: a role in carcinogenesis.

摘要: Apoptosis is a fundamental process that contributes to tissue homeostasis, immune responses, and development. The receptor CD95, also called Fas, member of the tumor necrosis factor (TNF-R) superfamily. Its cognate ligand, CD95L, implicated in homeostasis surveillance, various lineages malignant cells exhibit loss-of-function mutations this pathway; therefore, CD95 was initially classified as suppressor gene. However, more recent data indicate different pathophysiological contexts, can transmit non-apoptotic signals, promote inflammation, contribute carcinogenesis. A comparison with initial molecular events TNF-R signaling pathway leading non-apoptotic, apoptotic, necrotic pathways reveals probably using mechanisms its signals (NF-κB, MAPK, PI3K). As discussed review, by which switches from an apoptotic function inflammatory role unknown. More importantly, biological functions these remain elusive.