Mannose shows antitumour properties against lung cancer via inhibiting proliferation, promoting cisplatin‑mediated apoptosis and reducing metastasis.

摘要: It has been reported that mannose exerts antitumour effects against certain types of cancer. The present study was designed to evaluate whether exerted potential anticancer on A549 and H1299 non‑small cell lung cancer (NSCLC) cells in vitro, which not previously. A Cell Counting Kit‑8 viability assay used assess the antiproliferative NSCLC cells. Flow cytometry‑based methods were cycle distribution cisplatin‑mediated apoptosis Transwell migration invasion assays conducted examine could inhibit invasive abilities PI3K/AKT ERK signalling pathways explored through western blot analysis assessing expression phosphorylated (p)‑AKT p‑ERK1/2. found showed vitro by inhibiting proliferation, inducing G0/G1 arrest, promoting cisplatin‑induced decreasing abilities. These data indicate properties suggest application mannose‑based therapies treat NSCLC.