Studies on dexamethasone metabolism in man: effect of diphenylhydantoin.

摘要: Plasma kinetics and metabolism of labeled dexamethasone were evaluated in nine subjects before after administration diphenylhydantoin. Labeled was injected intravenously followed by frequent sampling blood urine. The plasma isolated chromatographically. Total urine fractional radioactivity solvent extraction (chloroform ethyl acetate), with without glucuronide hydrolysis, determined. Baseline equilibrated t½'s metabolic clearance rates (2 compartment model) ranged from 167 to 368 minutes 222 456 liters/day, respectively. After diphenylhydantoin there consistent decreases increases rate; mean changes —51% +140% Mean recovery urinary at 4 24 hours 16 64 percent dose largest fraction a more polar unconjugated one, 7 31 hours. Following signi...