Activin A as a Mediator of NK–Dendritic Cell Functional Interactions
作者： Pascal Seeger , Daniela Bosisio , Silvia Parolini , Raffaele Badolato , Angela Gismondi
关键词: Activin type 2 receptors 、 Interleukin 8 、 Downregulation and upregulation 、 Dendritic cell 、 Cell activation 、 Proinflammatory cytokine 、 Follistatin 、 Biology 、 Cell biology 、 CD1
摘要: The interaction of NK cells with dendritic (DCs) results in reciprocal cell activation through the membrane proteins and release soluble factors. In this article, we report that NK-DC cocultures, among a set 84 cytokines investigated, activin A was second highest induced gene, CXCL8 being most upregulated one. Activin is member TGF-β superfamily previously shown to possess both proinflammatory anti-inflammatory activities. induction required contact dependent on presence (i.e., IFN-γ, TNF-α, GM-CSF), as well cell-mediated DC killing. CD1(+) DCs were main producer myeloid blood subsets. inhibition by follistatin, natural inhibitory protein, or specific blocking Ab, resulted upregulation cytokine IL-6, IL-8, TNF-α) increase maturation. conclusion, our study reports A, produced during interactions, represents relevant negative feedback mechanism might function prevent excessive immune DCs.
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