Conditioned pain modulation evoked by different intensities of mechanical stimuli applied to the craniofacial region in healthy men and women.

摘要: Aims: To investigate systematically whether conditioned pain modulation (CPM) evoked by tonic mechanical stimuli applied to the craniofacial region is intensity-, assessment site-, and gender-dependent. Methods: Twenty healthy men 20 women participated in four sessions. Tonic painful stimulation was pericranial muscles a headband pressure device. The pressures probes were adjusted via feedback from 0 10 electronic visual analog scale (VAS) generate different levels (VAS0, VAS1, VAS3, or VAS5) for minutes. Pressure thresholds (PPTs) tolerance (PPTols) assessed right masseter muscle left forearm algometry before, during, immediately after, minutes after conditioning stimulus (CS). Data analyzed with multilevel ANOVAs. Results: PPT values normalized baseline recordings not dependent on gender site, but intensity (P < .001) time .001). most CS (VAS5) associated highest increases (32.6% ± 3.3%, mean value two sites genders) during compared all other intensities of PPTol also higher (11.2% 2.8%, .001). Conclusion: CPM intensity-dependent site- gender-dependent.