Impact of Polymer Pore Size on the Interface Scar Formation in a Rat Model

摘要: Abstract Background. The surgical therapy of hernias is increasingly based on reinforcement with alloplastic material, in particular meshes. biological response to these foreign bodies largely depends the selected material and its structure. In comparison physiological scar process following a simple abdominal wall incision, chronic inflammation at interface polymers lead specific morphological alterations. Materials methods. present study two meshes different pore sizes were implanted into rats: heavy-weight small-pore-sized mesh (hw-mesh) made nonabsorbable polypropylene monofilaments low-weight large-pore-sized consisting absorbable polyglactin multifilaments (lw-mesh). A suture repair laparotomy served as control. After 7, 14, 21, 90 days area was analyzed regard tissue cellular response. Results. Over whole observation period morphometric analysis indicated an improved integration lw-mesh reduction both fibrosis, whereas hw-mesh induced intense concomitant intensified bridging reaction. On level findings correspond elevated cell turnover, characterized by increased rates apoptotic proliferating cells. contrast, reaction achieved levels almost similar those scaring control group. Conclusion. conclusion, data confirm development inflammatory body hw-meshes lw-meshes; however, use lw-meshes showed superior integration. With quite polymer surface size appears be major importance for biocompatibility structures.