Extrastriatal monoaminergic dysfunction and enhanced microglial activation in idiopathic rapid eye movement sleep behaviour disorder

摘要: Abstract Background The majority of patients diagnosed with idiopathic rapid eye movement sleep behaviour disorder (iRBD) progress over time to a Lewy-type α-synucleinopathy such as Parkinson's disease or dementia Lewy bodies. This in vivo molecular imaging study aimed investigate if extrastriatal monoaminergic systems are affected iRBD and this coincides neuroinflammation. Methods We studied twenty-one polysomnography-confirmed 18F-DOPA 11C-PK11195 positron emission tomography (PET) function microglial activation. Twenty-nine healthy controls (n = 9 n = 20 11C-PK11195) were also investigated. Analyses performed within predefined regions interest at voxel-level Statistical Parametric Mapping. Results Regions analysis detected dysfunction thalamus 15% mean reduction Ki values compared (mean difference = −0.00026, 95% confidence interval [−0.00050 −0.00002], p-value = 0.03). No associated thalamic changes binding observed. Other sampled showed no PET differences between groups. Voxel-level interrogation identified areas significantly increased the occipital lobe patients. Conclusion Thalamic may reflect terminal projecting neurons from locus coeruleus dorsal raphe nucleus, two structures that regulate REM known be involved early phase PD. observation raised activation these might suggest local α-synuclein pathology possibly an risk for later cognitive dysfunction.