Timing of initiation of adjuvant chemotherapy for gastric cancer: A case-matched comparison study of laparoscopic vs. open surgery.

摘要: Abstract Background Laparoscopic gastrectomy (LG) is reported to be associated with faster recovery than open (OG); however, the influence of surgical approach on initiation timing adjuvant chemotherapy (AC) remains unclear. Methods This was a single-institutional retrospective observational study. Patients pathological stage II/III gastric cancer undergoing LG D2 lymphadenectomy (LG group: n = 74) were matched 1:1 patients selected from 214 similar OG (OG n = 74), identically matching gender, age, stage, and type gastrectomy, comparing AC between two groups. Factors delayed investigated in multivariable analysis. Results performed 86.5% 83.8% (OG) ( p =  0.64). The median time interval before significantly shorter vs. group (5.7 6.6 weeks, respectively, p 6 weeks) were: morbidity (≥grade 3a; odds ratio (OR): 16.1, 95% confidence (CI): 1.86–143), surgery (OR: 5.17, CI: 2.50–13.1), postoperative weight loss ≥ 8% 2.47, 1.07–5.71). Conclusions may intervals AC. Postoperative should reduced as much possible.