XRCC1 Polypeptide Interacts with DNA Polymerase β and Possibly Poly (ADP-Ribose) Polymerase, and DNA Ligase III Is a Novel Molecular ‘Nick-Sensor’ In Vitro
作者： K. W. Caldecott , S. Aoufouchi , P. Johnson , S. Shall
关键词: Biochemistry 、 DNA polymerase II 、 In vitro recombination 、 DNA polymerase mu 、 Polymerase 、 DNA polymerase 、 DNA polymerase I 、 DNA ligase 、 DNA clamp 、 Biology
摘要: The DNA repair proteins XRCC1 and ligase III are physically associated in human cells directly interact vitro vivo. Here, we demonstrate that is additionally with polymerase-beta these polypeptides also interact. We present data suggesting poly (ADP-ribose) polymerase can XRCC1. Finally, shares the novel function of a molecular nick-sensor, inhibit activity latter polypeptide vitro. Taken together, suggest four described above may be co-ordinated within single multiprotein complex.
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