Non-stealth (poly(lactic acid/albumin)) and stealth (poly(lactic acid-polyethylene glycol)) nanoparticles as injectable drug carriers

摘要: Abstract Stealth liposomes and, today, stealth nanoparticles, constitute a new generation of parenteral therapeutic systems. PLA/ abumin nanoparticles are particular interest because they fully biodegradable and well tolerated colloidal suspensions. Solvent evaporation microfluidisation did not damage the albumin molecules; therefore, PLA/albumin no more immunogenic than native in solution. However, rapid exchanges on nanoparticle surface probably does prevent C3-complement binding phagocytosis by liver Kupffer cells. Because their possible intracellular accumulation toxicity, presumably limited to subcutaneous or intramuscular administration. Poly( d,l -lactide)-poly (ethylene glycol) (PLA-PEG) is hydrophobic dibloc copolymer. The oriented PEG layer, coating surface, dramatically increases plasma half-life carrier (‘stealth nanoparticles’ ). In this way, PLAPEG about 6 h instead few minutes as for PLA/poloxamer 188-coated nanoparticles. clearance water-insoluble drug encapsulated administered intravenously, decreases very significantly comparison with non-stealth can be considered sustained release (intravenous) dosage form.