Rationale for targeting the Wnt signalling modulator Dickkopf-1 for oncology.
作者： Michael H Kagey , Xi He
DOI: 10.1111/BPH.13894
关键词: Wnt signaling pathway 、 Autocrine signalling 、 Internal medicine 、 Signal transduction 、 Metastasis 、 Cancer 、 Cell biology 、 Biology 、 Review article 、 DKK1 、 Tissue homeostasis 、 Oncology
摘要: Wnt signaling is a fundamental pathway involved in embryonic development and adult tissue homeostasis. Mutations the frequently lead to developmental defects cancer. As such, therapeutic intervention of this has generated tremendous interest. Dickkopf-1 (DKK1) secreted inhibitor β-catenin dependent was originally characterized as tumor suppressor based on prevailing view that promotes cancer pathogenesis. However, DKK1 appears increase growth metastasis pre-clinical models its elevated expression correlates with poor prognosis range cancers, indicating more complex cellular biological functions than appreciated. Here we review current evidence for promoting activity recent insights into effects pathways both immune cells. We discuss rationale promise targeting oncology.
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