Acetylcholinesterase Inhibitory and Antioxidant Activities of Novel Symmetric Sulfamides Derived from Phenethylamines
作者： Kadir Aksu , Fevzi Topal , İlhami Gulcin , Ferhan Tümer , Süleyman Göksu
关键词: Reagent 、 Phenethylamines 、 Chelating Activity 、 Antioxidant 、 Chelation 、 Chemistry 、 DPPH 、 ABTS 、 Medicinal chemistry 、 Sulfamide 、 Organic chemistry
摘要: The antioxidant and acetylcholinesterase inhibitory properties of novel symmetric sulfamides derived from phenethylamines were evaluated. Phenethylamines 8-11 reacted with SO2Cl2 in the presence Et3N to afford good yields. synthesized converted their phenolic derivatives BBr3. We elucidated activity by using different bioanalytical assays. For this purpose, radical scavenging activities assessed DPPH(•), ABTS(•+), DMPD(•+), O2(•-) tests. In addition, reducing abilities evaluated Fe(3+)-Fe(2+) reducing, Cu(2+)-Cu(+) [Fe(3+)-(TPTZ)2](3+)-[Fe(2+)-(TPTZ)2](2+) Also, Fe(2+) chelating pipyrdyl reagent studied. Especially, 16-19 showed high properties. On other hand, IC50 values calculated for scavenging, metal chelating, inhibition effects sulfamides.
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