Ischemic preconditioning provides no additive clinical value in liver resection of cirrhotic and non-cirrhotic patients under portal triad clamping: a prospective randomized controlled trial.

摘要: Summary Background and objective The clinical value of ischemic preconditioning (IP) on patients undergoing hepatectomy under portal triad clamping (PTC) is uncertain, especially for with liver cirrhosis. Hence, we conducted a prospective randomized controlled trial to test whether IP could protect against reperfusion (IR) injury after PTC. Method One hundred patients, including 67 cirrhosis, PTC were randomly divided into control groups. Liver function tests at postoperative days 1, 3, 7 as well morbidity, mortality, duration hospitalization compared between the two Results general characteristics both groups comparable. operation, amount intraoperative blood loss, need perioperative transfusion similar in levels serum alanine aminotransferase (ALT), aspartate (AST), total bilirubin, albumin not statistically different In addition, morbidity mortality rates Conclusions did improve tolerance IR Therefore, use cannot be recommended standard procedure before