Tissue distribution of the dystrophin-related gene product and expression in the mdx and dy mouse.
作者： D. R. Love , G. E. Morris , J. M. Ellis , U. Fairbrother , R. F. Marsden
关键词: Dystrophin 、 Gene expression 、 Gene 、 Locus (genetics) 、 Messenger RNA 、 Duchenne muscular dystrophy 、 Molecular biology 、 Gene product 、 Fusion protein 、 Biology
摘要: Abstract We have previously reported a dystrophin-related locus (DMDL for Duchenne muscular dystrophy-like) on human chromosome 6 that maps close to the dy mutation mouse 10. Here we show this gene is expressed in wide range of tissues at varying levels. The transcript particularly abundant several fetal tissues, including heart, placenta, and intestine. Studies with antisera raised against DMDL fusion protein identify 400,000 Mr all tested, those mdx mice. Unlike dystrophin gene, not differentially spliced 3' end either muscle or brain.
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Simon C. Watkins, Eric P. Hoffman, Henry S. Slayter, Louis M. Kunkel, Immunoelectron microscopic localization of dystrophin in myofibres. Nature. ,vol. 333, pp. 863- 866 ,(1988) , 10.1038/333863A0
Elizabeth E. Zubrzycka-Gaarn, Dennis E. Bulman, George Karpati, Arthur H. M. Burghes, Bonnie Belfall, Henry J. Klamut, Jim Talbot, Robert S. Hodges, Peter N. Ray, Ronald G. Worton, The Duchenne muscular dystrophy gene product is localized in sarcolemma of human skeletal muscle Nature. ,vol. 333, pp. 466- 469 ,(1988) , 10.1038/333466A0
G. Gillespie, J. Lloyd, D. Hopkinson, Y. Edwards, The 3′-untranslated sequence of human skeletal muscle α-actin mRNA Journal of Muscle Research and Cell Motility. ,vol. 5, pp. 457- 464 ,(1984) , 10.1007/BF00818263
Tom Maniatis, Joseph Sambrook, E. F. Fritsch, Molecular Cloning: A Laboratory Manual ,(2001)