Molecular inversion probe assay.
作者： Farnaz Absalan , Mostafa Ronaghi
DOI: 10.1007/978-1-59745-515-2_20
关键词: Computational biology 、 Genotyping 、 Genetic variation 、 Allele 、 International HapMap Project 、 Molecular Inversion Probe 、 Computer science
摘要: We have described molecular inversion probe technologies for large-scale genetic analyses. This technique provides a comprehensive and powerful tool the analysis of variation enables affordable, studies that will help uncover basis complex disease explain individual in response to therapeutics. Major applications probes (MIP) include targeted genotyping from focused regions whole-genome studies, allele quantification genomic rearrangements. The MIP technology (used HapMap project) an efficient, scalable, affordable way score polymorphisms case/control populations studies. highest commercially available multiplexing levels assay conversion rates genotyping. more informative, genome-wide with either functional (direct detection) approach or indirect detection approach.
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sci-hub.se 参考文章(5)
Paul Hardenbol, Johan Banér, Maneesh Jain, Mats Nilsson, Eugeni A Namsaraev, George A Karlin-Neumann, Hossein Fakhrai-Rad, Mostafa Ronaghi, Thomas D Willis, Ulf Landegren, Ronald W Davis, Multiplexed genotyping with sequence-tagged molecular inversion probes Nature Biotechnology. ,vol. 21, pp. 673- 678 ,(2003) , 10.1038/NBT821
Martin Moorhead, Paul Hardenbol, Farooq Siddiqui, Matthew Falkowski, Carsten Bruckner, James Ireland, Hywel B Jones, Maneesh Jain, Thomas D Willis, Malek Faham, Optimal genotype determination in highly multiplexed SNP data European Journal of Human Genetics. ,vol. 14, pp. 207- 215 ,(2006) , 10.1038/SJ.EJHG.5201528
James Ireland, Victoria E.H. Carlton, Matthew Falkowski, Martin Moorhead, Karen Tran, Francisco Useche, Paul Hardenbol, Ayca Erbilgin, Ron Fitzgerald, Thomas D. Willis, Malek Faham, Large-scale characterization of public database SNPs causing non-synonymous changes in three ethnic groups Human Genetics. ,vol. 119, pp. 75- 83 ,(2006) , 10.1007/S00439-005-0105-X
Yuker Wang, Martin Moorhead, George Karlin-Neumann, Matthew Falkowski, Chunnuan Chen, Farooq Siddiqui, Ronald W Davis, Thomas D Willis, Malek Faham, Allele quantification using molecular inversion probes (MIP) Nucleic Acids Research. ,vol. 33, ,(2005) , 10.1093/NAR/GNI177
Paul Hardenbol, Fuli Yu, John Belmont, Jennifer MacKenzie, Carsten Bruckner, Tiffany Brundage, Andrew Boudreau, Steve Chow, Jim Eberle, Ayca Erbilgin, Mat Falkowski, Ron Fitzgerald, Sy Ghose, Oleg Iartchouk, Maneesh Jain, George Karlin-Neumann, Xiuhua Lu, Xin Miao, Bridget Moore, Martin Moorhead, Eugeni Namsaraev, Shiran Pasternak, Eunice Prakash, Karen Tran, Zhiyong Wang, Hywel B Jones, Ronald W Davis, Thomas D Willis, Richard A Gibbs, Highly multiplexed molecular inversion probe genotyping: Over 10,000 targeted SNPs genotyped in a single tube assay Genome Research. ,vol. 15, pp. 269- 275 ,(2005) , 10.1101/GR.3185605