The mitochondrial Italian Human Proteome Project initiative (mt-HPP).

摘要: Mitochondria carry maternally inherited genetic material, called the mitochondrial genome (mtDNA), which can be defined as 25th human chromosome. The chromosome-centric Human Proteome Project (c-HPP) has initially focused its activities addressing characterization and quantification of nuclear encoded proteins. Following last International HUPO Congress in Boston (September 2012) it was clear that however small chromosome is, plays an important role many biological physiopathological functions. Mutations mtDNA have been shown to associated with dozens unexplained disorders information contained should major relevance understanding diseases. Within this paper we describe Italian initiative dedicated mitochondria part both programs: Biology/Disease (B/D-HPP). mt-HPP finally shifted attention community outside chromosomes general purpose highlight processes influencing health. vision considering large interest evidence collected on non-Mendelian heredity Homo sapiens mt-chromosome microbial commensal ecosystem constituting our organism may speculate program will represent initial step toward other HPP initiatives focusing phenotypic heredity.