Hypoxia-related molecules HIF-1α, CA9, and osteopontin : predictors of survival in patients with high-grade glioma.
作者： O.P. Erpolat , P.U. Gocun , M. Akmansu , G. Ozgun , G. Akyol
DOI: 10.1007/S00066-012-0262-5
关键词: Medicine 、 Survival rate 、 Survival analysis 、 Carbonic Anhydrase 9 、 Glioma 、 Immunohistochemistry 、 Cancer research 、 Hypoxia (medical) 、 Osteopontin 、 Targeted therapy 、 Pathology
摘要: A high expression of hypoxia-inducible factor-1 alpha (HIF)-1α, carbonic anhydrase 9 (CA9), and osteopontin appears to be a strong prognostic indicator in many malignancies; however, their role is unclear high-grade gliomas. HIF-1α, CA9, levels tissue specimens 92 patients with glioma were evaluated by immunohistochemistry. Patients cytoplasmic nuclear had significantly shorter overall survival. The results these markers combined form hypoxic profile, scores (expression two or three markers) correlated poorer In multivariate analysis, score-1 (cytoplasmic osteopontin) was the only independent negative factor for survival (p = 0.028). Our showed that combination more robust than single marker predicting glioma. It may necessary utilize score selecting targeted therapy future.
springer.com
sci-hub.se 参考文章(31)
D. Schilling, C. Bayer, K. Emmerich, M. Molls, P. Vaupel, R.M. Huber, G. Multhoff, Basal HIF-1α expression levels are not predictive for radiosensitivity of human cancer cell lines Strahlentherapie Und Onkologie. ,vol. 188, pp. 353- 358 ,(2012) , 10.1007/S00066-011-0051-6
Dirk Vordermark, J. Martin Brown, Endogenous markers of tumor hypoxia predictors of clinical radiation resistance Strahlentherapie Und Onkologie. ,vol. 179, pp. 801- 811 ,(2003) , 10.1007/S00066-003-1150-9
Giampiero Ausili Céfaro, Domenico Genovesi, Annamaria Vinciguerra, Marianna Trignani, Maria Taraborrelli, Antonietta Augurio, Roberto Buonaguidi, Renato J. Galzio, Marta Di Nicola, Prognostic impact of hemoglobin level and other factors in patients with high-grade gliomas treated with postoperative radiochemotherapy and sequential chemotherapy based on temozolomide: a 10-year experience at a single institution. Strahlentherapie Und Onkologie. ,vol. 187, pp. 778- 783 ,(2011) , 10.1007/S00066-011-1129-X
S. Yamamoto, Y. Ushio, J.-I. Kuratsu, Y. Saitoh, H. Takeshima, Expression of osteopontin in human glioma. Its correlation with the malignancy. Laboratory Investigation. ,vol. 72, pp. 55- 63 ,(1995)
Adrian Staab, Markus Fleischer, Juergen Loeffler, Harun M. Said, Astrid Katzer, Christian Plathow, Herrmann Einsele, Michael Flentje, Dirk Vordermark, Small interfering RNA targeting HIF-1α reduces hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitro. Strahlentherapie Und Onkologie. ,vol. 187, pp. 252- 259 ,(2011) , 10.1007/S00066-011-2167-0
Georg Oberhuber, Peter Birner, Gerhard Breitenecker, Monika Schindl, Andreas Obermair, Christina Plank, Overexpression of Hypoxia-inducible Factor 1α Is a Marker for an Unfavorable Prognosis in Early-Stage Invasive Cervical Cancer Cancer Research. ,vol. 60, pp. 4693- 4696 ,(2000)
Quynh-Thu Le, Christina Kong, Phillip W. Lavori, Ken O'Byrne, Janine T. Erler, Xin Huang, Yijun Chen, Hongbin Cao, Robert Tibshirani, Nic Denko, Amato J. Giaccia, Albert C. Koong, Expression and Prognostic Significance of a Panel of Tissue Hypoxia Markers in Head-and-Neck Squamous Cell Carcinomas International Journal of Radiation Oncology Biology Physics. ,vol. 69, pp. 167- 175 ,(2007) , 10.1016/J.IJROBP.2007.01.071
M HOCKEL, Biological consequences of tumor hypoxia Seminars in Oncology. ,vol. 28, pp. 36- 41 ,(2001) , 10.1016/S0093-7754(01)90211-8
Nobuyuki Irie, Takayuki Matsuo, Izumi Nagata, Protocol of radiotherapy for glioblastoma according to the expression of HIF-1. Brain Tumor Pathology. ,vol. 21, pp. 1- 6 ,(2004) , 10.1007/BF02482169
Gregg L. Semenza, Targeting HIF-1 for cancer therapy Nature Reviews Cancer. ,vol. 3, pp. 721- 732 ,(2003) , 10.1038/NRC1187