Erythromycin and clindamycin absorption and elimination in pregnant women.

摘要: Thirty-nine pregnant women admitted for therapeutic abortions during early or mid pregnancy were given erythromycin estolate, base, clindamycin hydrochloride orally in single multiple doses. Peak serum levels of 3.4 to 9.0 mug/ml following a dose 450 mg, whereas peak 0.29 7.2 500 mg dose. The individual variability concentrations was greater than that reported normal men and nonpregnant women, the rather uniform, similar what has been individuals. Following doses each antibiotic, high obtained virtually all subjects, urine also higher. mean urinary recovery 2% 16.8% clindamycin.