Dysregulated CRTC1 activity is a novel component of PGE2 signaling that contributes to colon cancer growth.
作者： Y Schumacher , T Aparicio , S Ourabah , F Baraille , A Martin
DOI: 10.1038/ONC.2015.283
关键词: Amphiregulin 、 Colorectal cancer 、 Signal transduction 、 Cell cycle 、 Biology 、 Azoxymethane 、 Cancer research 、 Immunology 、 CREB 、 Carcinogenesis 、 Growth factor receptor
摘要: … by CRTC1/CREB and CRTC1/AP1 complexes in colonic cancer epithelial cells and identify CRTC1 as … of PGE2 signaling and their downstream pro-tumorigenic targets in colon cancer. …
nature.com
sci-hub.se 
researchgate.net 参考文章(59)
Masahiro Sonoshita, Kazuaki Takaku, Nobuya Sasaki, Yukihiko Sugimoto, Fumitaka Ushikubi, Shuh Narumiya, Masanobu Oshima, Makoto M. Taketo, Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice Nature Medicine. ,vol. 7, pp. 1048- 1051 ,(2001) , 10.1038/NM0901-1048
Yolanda Alvarez, Cristina Municio, Sara Alonso, Mariano Sánchez Crespo, Nieves Fernández, The Induction of IL-10 by Zymosan in Dendritic Cells Depends on CREB Activation by the Coactivators CREB-Binding Protein and TORC2 and Autocrine PGE2 Journal of Immunology. ,vol. 183, pp. 1471- 1479 ,(2009) , 10.4049/JIMMUNOL.0900312
Su-Jin Kim, Cuilan Nian, Scott Widenmaier, Christopher H. S. McIntosh, Glucose-Dependent Insulinotropic Polypeptide-Mediated Up-Regulation of β-Cell Antiapoptotic Bcl-2 Gene Expression Is Coordinated by Cyclic AMP (cAMP) Response Element Binding Protein (CREB) and cAMP-Responsive CREB Coactivator 2 Molecular and Cellular Biology. ,vol. 28, pp. 1644- 1656 ,(2008) , 10.1128/MCB.00325-07
Yi Liu, Renaud Dentin, Danica Chen, Susan Hedrick, Kim Ravnskjaer, Simon Schenk, Jill Milne, David J. Meyers, Phil Cole, John Yates III, Jerrold Olefsky, Leonard Guarente, Marc Montminy, A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange Nature. ,vol. 456, pp. 269- 273 ,(2008) , 10.1038/NATURE07349
Michael J. Guzman, Jinyi Shao, Hongmiao Sheng, Pro-Neoplastic Effects of Amphiregulin in Colorectal Carcinogenesis Journal of Gastrointestinal Cancer. ,vol. 44, pp. 211- 221 ,(2013) , 10.1007/S12029-012-9474-2
Lizi Wu, Jingxuan Liu, Ping Gao, Makoto Nakamura, Yang Cao, Huangxuan Shen, James D Griffin, Transforming activity of MECT1‐MAML2 fusion oncoprotein is mediated by constitutive CREB activation The EMBO Journal. ,vol. 24, pp. 2391- 2402 ,(2005) , 10.1038/SJ.EMBOJ.7600719
Agnes Rasmuson, Anna Kock, Ole Martin Fuskevåg, Björn Kruspig, Jaione Simón-Santamaría, Vladimir Gogvadze, John Inge Johnsen, Per Kogner, Baldur Sveinbjörnsson, Autocrine Prostaglandin E2 Signaling Promotes Tumor Cell Survival and Proliferation in Childhood Neuroblastoma PLoS ONE. ,vol. 7, pp. e29331- ,(2012) , 10.1371/JOURNAL.PONE.0029331
Chunxia Cao, Ruli Gao, Min Zhang, Antonio L. Amelio, Mohammad Fallahi, Zirong Chen, Yumei Gu, Chengbin Hu, Eric A. Welsh, Brienne E. Engel, Eric B. Haura, W. Douglas Cress, Lizi Wu, Maria Zajac-Kaye, Frederic J. Kaye, Role of LKB1-CRTC1 on Glycosylated COX-2 and Response to COX-2 Inhibition in Lung Cancer Journal of the National Cancer Institute. ,vol. 107, pp. 358- 358 ,(2015) , 10.1093/JNCI/DJU358
Simon Chell, Abderrahmane Kadi, Ann Caroline Williams, Christos Paraskeva, Mediators of PGE2 synthesis and signalling downstream of COX-2 represent potential targets for the prevention/treatment of colorectal cancer Biochimica et Biophysica Acta. ,vol. 1766, pp. 104- 119 ,(2006) , 10.1016/J.BBCAN.2006.05.002
Z Chen, J Chen, Y Gu, C Hu, J-L Li, S Lin, H Shen, C Cao, R Gao, J Li, P K Ha, F J Kaye, J D Griffin, L Wu, Aberrantly activated AREG–EGFR signaling is required for the growth and survival of CRTC1–MAML2 fusion-positive mucoepidermoid carcinoma cells Oncogene. ,vol. 33, pp. 3869- 3877 ,(2014) , 10.1038/ONC.2013.348