HEMODYNAMIC DESIGN OPTIMIZATION OF A VENTRICULAR CANNULA:EVALUATION AND IMPLEMENTATION OF OBJECTIVE FUNCTIONS

摘要: Shape optimization has been used for decades to improve the aerodynamic performance of automobiles and aircraft. The application this technology blood-wetted medical devices have limited, in part, due ambiguity hemodynamic variables associated with biocompatibility - specifically hemolysis, platelet activation, thrombus formation. This study undertook a systematic evaluation several objective functions derived directly from flow field. We focused on two-dimensional blood conduit (cannula) by allowing free variation centerline cross-sectional area. was simulated using computational fluid dynamics (CFD) at nominal rate 6 lpm boundary conditions consistent an abdominally positioned left-ventricular-assist device (LVAD). objectives were evaluated both locally globally. results demonstrated similarities between four functions: vorticity, viscous dissipation, principal shear stress, power-law (PL) damage models based history. Of analyzed, those found be most indicative separation clearance deviation index Peclet Number. conclusions these studies will applied ongoing development algorithms optimizing path rotary pumps, cannula, other contacting devices.