Design, synthesis, and biological evaluation of thiophene analogues of chalcones
作者： Romeo Romagnoli , Pier Giovanni Baraldi , Maria Dora Carrion , Carlota Lopez Cara , Olga Cruz-Lopez
DOI: 10.1016/J.BMC.2008.04.026
关键词: Ether 、 Enone 、 Tubulin 、 Thiophene 、 Chemistry 、 Double bond 、 Stereochemistry 、 Moiety 、 Aryl 、 Chemical synthesis
摘要: … A series of molecular modelling studies were carried out on this class of compounds. Structure alignment between chalcone 1f and thiophene … be replaced by the heterocyclic ring as a …
core.ac.uk
elsevier.com
sci-hub.se 参考文章(16)
Ernest Hamel, Evaluation of antimitotic agents by quantitative comparisons of their effects on the polymerization of purified tubulin. Cell Biochemistry and Biophysics. ,vol. 38, pp. 1- 21 ,(2003) , 10.1385/CBB:38:1:1
Qun Li, Hing L Sham, Discovery and development of antimitotic agents that inhibit tubulin polymerisation for the treatment of cancer Expert Opinion on Therapeutic Patents. ,vol. 12, pp. 1663- 1702 ,(2002) , 10.1517/13543776.12.11.1663
Romeo Romagnoli, Pier Giovanni Baraldi, Vincent Remusat, Maria Dora Carrion, Carlota Lopez Cara, Delia Preti, Francesca Fruttarolo, Maria Giovanna Pavani, Mojgan Aghazadeh Tabrizi, Manlio Tolomeo, Stefania Grimaudo, Jan Balzarini, Mary Ann Jordan, Ernest Hamel, Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors. Journal of Medicinal Chemistry. ,vol. 49, pp. 6425- 6428 ,(2006) , 10.1021/JM060804A
Bidhan C. Roy, Gandhi K. Kar, Jayanta K. Ray, A Simple and New Synthetic Method for the Preparation of 2-Pheynl-6-substituted Quinolines Synthetic Communications. ,vol. 23, pp. 1959- 1965 ,(1993) , 10.1080/00397919308009854
Arindam Chakraborty, Jayanta K. Ray, On the Regio and Stereo Selective Formylations of Acyclic Alpha Methylene Ketones towards Vilsmeier Haack Reagent Synthetic Communications. ,vol. 25, pp. 1869- 1876 ,(1995) , 10.1080/00397919508015433
Allan Jordan, John A. Hadfield, Nicholas J. Lawrence, Alan T. McGown, Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Medicinal Research Reviews. ,vol. 18, pp. 259- 296 ,(1998) , 10.1002/(SICI)1098-1128(199807)18:4<259::AID-MED3>3.0.CO;2-U
Regan LeBlanc, John Dickson, Toni Brown, Michelle Stewart, Hari N. Pati, Don VanDerveer, Hadi Arman, Jeff Harris, William Pennington, Herman L. Holt, Moses Lee, Synthesis and cytotoxicity of epoxide and pyrazole analogs of the combretastatins. Bioorganic & Medicinal Chemistry. ,vol. 13, pp. 6025- 6034 ,(2005) , 10.1016/J.BMC.2005.06.028
B.A. Bhat, K.L. Dhar, S.C. Puri, A.K. Saxena, M. Shanmugavel, G.N. Qazi, Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents. Bioorganic & Medicinal Chemistry Letters. ,vol. 15, pp. 3177- 3180 ,(2005) , 10.1016/J.BMCL.2005.03.121
Jose M. Andreu, Bernardo Perez-Ramirez, Marina J. Gorbunoff, David Ayala, Serge N. Timasheff, ROLE OF THE COLCHICINE RING A AND ITS METHOXY GROUPS IN THE BINDING TO TUBULIN AND MICROTUBULE INHIBITION Biochemistry. ,vol. 37, pp. 8356- 8368 ,(1998) , 10.1021/BI9728553
George R. Pettit, Gordon M. Cragg, Delbert L. Herald, Jean M. Schmidt, Prasert Lohavanijaya, Isolation and structure of combretastatin Canadian Journal of Chemistry. ,vol. 60, pp. 1374- 1376 ,(1982) , 10.1139/V82-202