Pattern and predictability in memory formation: from molecular mechanisms to clinical relevance.

摘要: Most long-term memories are formed as a consequence of multiple experiences. The temporal spacing these experiences is considerable importance: distributed over time (spaced training) more easily encoded and remembered than either closely spaced experiences, or single prolonged experience (massed training). In this article, we first review findings from studies in animal model systems that examine the cellular molecular properties neurons circuits brain underlie training pattern sensitivity during memory (LTM) formation. We next focus on recent which have begun to elucidate mechanisms support inter-trial interactions induction LTM. Finally, consider implications for developing therapeutic strategies address questions direct clinical relevance.