Molecular Studies of Members of the Mammalian Na+/H+ Exchanger Gene Family

摘要: The brief history of the contribution molecular biologic studies to understanding Na+/H+ exchanger gene family is not unlike other transport proteins. Many years results from physiologic and biochemical provided background allow strategies for recognition an initial member family. This was followed by existence a family, which even now only partially defined. Rapid advances concerning location, regulation, structure/function relationships, all have served extend previous studies. Current involve “torturing” specific proteins deletion point mutation creation chimeric constructs further explore These are descriptive that attempting gain clues as how carry out regulated. However, they fall short defining work, presumably will follow crystallagraphic techniques, although no mammalian protein has yet yielded required information using any approach or combination approaches.