Vaccination as a Novel Approach for Treating Depressive Behavior
作者： Gil M. Lewitus , Adi Wilf-Yarkoni , Yaniv Ziv , Maytal Shabat-Simon , Roman Gersner
DOI: 10.1016/J.BIOPSYCH.2008.07.014
关键词: Brain-derived neurotrophic factor 、 Neurogenesis 、 Antidepressant 、 Psychology 、 Central nervous system 、 Immune system 、 Neurotrophic factors 、 Neuroscience 、 Psychoneuroimmunology 、 Anhedonia 、 Immunology
摘要: Background Depressive behavior in animals is often associated with reduced levels of brain-derived neurotrophic factor (BDNF) and impaired neurogenesis the hippocampus. Recent studies showed that T cells recognizing central nervous system (CNS)-specific antigens can regulate adult hippocampal expression BDNF. On basis these findings, we hypothesized controlling CNS specific immune activity by immunization a myelin-related peptide may have an antidepressant effect. Methods We investigated impact related peptide, on behavioral cellular outcomes chronic mild stress (CMS; animal model for depression) rats. Results Immunization weak agonist myelin-derived ameliorated depressive such as anhedonia (measured sucrose preference), induced CMS The outcome was accompanied restoration BDNF neurogenesis. Conclusions results this study introduce novel approach CNS-related therapeutic means fighting depression. Vaccination, therapy, invoke several molecular pathways are known to be regulated drugs. Therefore, suggest immune-based therapies should considered treatment
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sci-hub.se 参考文章(24)
I MacPhee, D Mason, F Antoni, The role of the neuroendocrine system in determining genetic susceptibility to experimental allergic encephalomyelitis in the rat. Immunology. ,vol. 70, pp. 1- 5 ,(1990)
Gila Moalem, Raya Leibowitz–Amit, Eti Yoles, Felix Mor, Irun R. Cohen, Michal Schwartz, Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy Nature Medicine. ,vol. 5, pp. 49- 55 ,(1999) , 10.1038/4734
Erika Toth, Roman Gersner, Adi Wilf-Yarkoni, Hagit Raizel, Dalit E. Dar, Gal Richter-Levin, Ofir Levit, Abraham Zangen, Age-dependent effects of chronic stress on brain plasticity and depressive behavior. Journal of Neurochemistry. ,vol. 107, pp. 522- 532 ,(2008) , 10.1111/J.1471-4159.2008.05642.X
Amitabh Gaur, Stefen A Boehme, Derek Chalmers, Paul D Crowe, Anil Pahuja, Nicholas Ling, Stefan Brocke, Lawrence Steinman, Paul J Conlon, Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms Journal of Neuroimmunology. ,vol. 74, pp. 149- 158 ,(1997) , 10.1016/S0165-5728(96)00220-2
Tracy L Baker-Herman, David D Fuller, Ryan W Bavis, Andrea G Zabka, Francis J Golder, Nicholas J Doperalski, Rebecca A Johnson, Jyoti J Watters, Gordon S Mitchell, BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia Nature Neuroscience. ,vol. 7, pp. 48- 55 ,(2004) , 10.1038/NN1166
M. D. Mannie, P. Y. Paterson, D. C. U'Prichard, G. Flouret, Induction of experimental allergic encephalomyelitis in Lewis rats with purified synthetic peptides: delineation of antigenic determinants for encephalitogenicity, in vitro activation of cellular transfer, and proliferation of lymphocytes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 5515- 5519 ,(1985) , 10.1073/PNAS.82.16.5515
Roman Gersner, Dalit E. Dar, Maytal Shabat-Simon, Abraham Zangen, Behavioral analysis during the forced swimming test using a joystick device. Journal of Neuroscience Methods. ,vol. 143, pp. 117- 121 ,(2005) , 10.1016/J.JNEUMETH.2004.09.017
Janne Grønli, Clive Bramham, Robert Murison, Tambudzai Kanhema, Eldbjørg Fiske, Bjørn Bjorvatn, Reidun Ursin, Chiara M. Portas, Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper Pharmacology, Biochemistry and Behavior. ,vol. 85, pp. 842- 849 ,(2006) , 10.1016/J.PBB.2006.11.021
P. Willner, A. Towell, D. Sampson, S. Sophokleous, R. Muscat, Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology. ,vol. 93, pp. 358- 364 ,(1987) , 10.1007/BF00187257
Haiyun Xu, Zhong Chen, Jue He, Samson Haimanot, Xiaokun Li, Lillian Dyck, Xin‐Min Li, None, Synergetic effects of quetiapine and venlafaxine in preventing the chronic restraint stress‐induced decrease in cell proliferation and BDNF expression in rat hippocampus Hippocampus. ,vol. 16, pp. 551- 559 ,(2006) , 10.1002/HIPO.20184