IL-2 signals through Sgk1 and inhibits proliferation and apoptosis in kidney cancer cells.
作者： Rosario Amato , Miranda Menniti , Valter Agosti , Rosalia Boito , Nicola Costa
DOI: 10.1007/S00109-007-0205-2
关键词: Cytokine 、 Ectopic expression 、 SGK1 、 Endocrinology 、 Programmed cell death 、 Receptor 、 Interleukin 2 、 Biology 、 Apoptosis 、 Cancer research 、 Signal transduction 、 Internal medicine
摘要: The interleukin-2 is a cytokine that essential for lymphocytic survival and function. Ectopic expression of the IL-2 receptor in epithelial tissues has been reported previously, although functional significance this still being investigated. We provided novel structural information on kidney cancer cells other normal neoplastic human tissues. In A-498 cells, we showed binding to its own triggers signal transduction pathway leading inhibition proliferation apoptosis. found associated with Erk1/2 dephosphorylation, whereas signals appear be mediated by Sgk1 activation. This investigation focuses induced regulation describes role tumor cell death survival.
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