Apoptosis in Drosophila

摘要: Holometabolous insects, such as the dipteran Drosophila, exhibit two distinct life forms and undergo a complete metamorphosis. The Drosophila embryo develops over course of one day hatches into motile feeding first instar larva, which grows subsequently moults twice (Figure 1). second larval instars each last about day, while third lasts approximately three days. At end instar, animal ceases to feed, climbs up suitable substrate, initiates pupariation. pupal stage four days, during time larva metamorphoses adult fly. ease rearing their fecundity, short cycle have all contributed use genetic model system (see Ashburner, 1989). In addition, genome is relatively small (∼1.6 X 108 base pairs per haploid genome), organised only chromosomes are linked by common chromocentre. large polytene salivary gland greatly facilitate cytological mapping chromosomal rearrangements well localisation cloned genes via in situ hybridisation. balancer chromosomes, repress recombination provide dominant phenotypic markers, facilitates screens stable maintenance homozygous lethal chromosomes.