Wnt signaling agonist molecules

作者: Claudia Yvonne Janda , Kenan Christopher Garcia , Luke Dang , David Baker , James Daniel Moody

DOI:

关键词: Wnt signaling pathwayChemistryLRP6FrizzledAgonistCell biologyLRP5MoietyMoleculeConjugated system

摘要: Wnt signaling agonist compositions and methods for their use are provided. agonists of the invention comprise a frizzled binding moiety, which is fused or conjugated to an LRP5 LRP6 moiety.

参考文章(9)
Weilan Ye, Harald J. Junge, Methods for inhibiting ocular angiogenesis ,(2009)
Jennifer A. Getz, Jeffrey J. Rice, Patrick S. Daugherty, Protease-Resistant Peptide Ligands from a Knottin Scaffold Library ACS Chemical Biology. ,vol. 6, pp. 837- 844 ,(2011) , 10.1021/CB200039S
S. Minear, P. Leucht, J. Jiang, B. Liu, A. Zeng, C. Fuerer, R. Nusse, J. A. Helms, Wnt Proteins Promote Bone Regeneration Science Translational Medicine. ,vol. 2, ,(2010) , 10.1126/SCITRANSLMED.3000231
Jun Liu, Xu Wu, Brian Mitchell, Chris Kintner, Sheng Ding, Peter G. Schultz, A Small‐Molecule Agonist of the Wnt Signaling Pathway Angewandte Chemie. ,vol. 44, pp. 1987- 1990 ,(2005) , 10.1002/ANIE.200462552
Jiyuan Ke, Kaleeckal G Harikumar, Clara Erice, Chen Chen, Xin Gu, Liren Wang, Naomi Parker, Zhihong Cheng, Wenqing Xu, Bart O Williams, Karsten Melcher, Laurence J Miller, H Eric Xu, Structure and function of Norrin in assembly and activation of a Frizzled 4–Lrp5/6 complex Genes & Development. ,vol. 27, pp. 2305- 2319 ,(2013) , 10.1101/GAD.228544.113
Seth Ettenberg, Feng Cong, Andreas Loew, David Jenkins, Li Zhou, Karen Vincent, Ming Lei, Compositions and methods of use for therapeutic low density lipoprotein - related protein 6 (lrp6) multivalent antibodies ,(2011)
Aron Levin, Kenan Christopher Garcia, Wnt compositions and methods of use thereof ,(2012)