Preemptive management of dermatologic toxicities associated with epidermal growth factor receptor inhibitors.

作者: Jean Boucher , Linnea Olson , Bilal Piperdi

DOI: 10.1188/11.CJON.501-508

关键词: DiscontinuationIntensive care medicineEpidermal Growth Factor Receptor InhibitorsQuality of lifeMedicineEGF Signaling PathwayHead and neckPatient supportTreatment optionsTreatment regimen

摘要: Epidermal growth factor receptor inhibitors (EGFRIs) are a treatment option for patients diagnosed with advanced-stage gastrointestinal, lung, and head neck cancers. The most prevalent complications associated EGFRIs dermatologic toxicities, which may result in either disruption or discontinuation of adversely affect patients' quality life. Nurses play vital role educating about EGFRI-related toxicities; therefore, nurses must continue to educate themselves on the various aspects EGFRI treatment. An overview EGF signaling pathway is provided, toxicities described. A review several studies evaluating reactive skin regimens also discussed. critical providing patient support. Informing potential symptoms will help prepare their course In addition, should provide variety coping strategies manage that assist enhancing adherence

参考文章(41)
Mario E. Lacouture, Jonathan Cotliar, Edith P. Mitchell, Clinical management of EGFRI dermatologic toxicities: US perspective. Oncology. ,vol. 21, pp. 17- 21 ,(2007)
Eric Van Cutsem, Siegfried Segaert, Clinical management of EGFRI dermatologic toxicities: the European perspective. Oncology. ,vol. 21, pp. 22- 26 ,(2007)
Yosef Yarden, Mark X. Sliwkowski, Untangling the ErbB signalling network Nature Reviews Molecular Cell Biology. ,vol. 2, pp. 127- 137 ,(2001) , 10.1038/35052073
Aminah Jatoi, Kendrith Rowland, Jeff A. Sloan, Howard M. Gross, Paul A. Fishkin, Stephen P. Kahanic, Paul J. Novotny, Paul L. Schaefer, David B. Johnson, Loren K. Tschetter, Charles L. Loprinzi, Tetracycline to prevent epidermal growth factor receptor inhibitor-induced skin rashes: results of a placebo-controlled trial from the North Central Cancer Treatment Group (N03CB). Cancer. ,vol. 113, pp. 847- 853 ,(2008) , 10.1002/CNCR.23621
Karen Oishi, Clinical approaches to minimize rash associated with EGFR inhibitors. Oncology Nursing Forum. ,vol. 35, pp. 103- 111 ,(2008) , 10.1188/08.ONF.103-111
Ahmad D. Siddiqui, Bilal Piperdi, KRAS Mutation in Colon Cancer: A Marker of Resistance to EGFR-I Therapy Annals of Surgical Oncology. ,vol. 17, pp. 1168- 1176 ,(2010) , 10.1245/S10434-009-0811-Z
Beth Eaby, Ann Culkin, Mario E. Lacouture, An interdisciplinary consensus on managing skin reactions associated with human epidermal growth factor receptor inhibitors. Clinical Journal of Oncology Nursing. ,vol. 12, pp. 283- 290 ,(2008) , 10.1188/08.CJON.283-290