Experimental determination of the regional deposition of aerosol particles in the human respiratory tract.

摘要: The experimental techniques and the results of inhalation studies with radioaerosols on normal non-smokers for mouth-breathing are described discussed. Monodisperse iron oxide particles tagged with198Au produced a spinning top generator in aerodynamic size range between 1 to 10 µm. An aerosol apparatus enables subjects breathe under standardized conditions respect tidal volume breathing frequency. calculation total deposition is based upon measurements number in- exhaled per breath by means photometric methods pneumotachography. retention radioactive present body after administration measured counter designed constructed these experiments. Retention as functions time carried out extrathoracic-, chest- stomach-position. consists four shielded NaF(TI)-detectors. geometrical arrangement, collimat...