COL5A1 may contribute the metastasis of lung adenocarcinoma.

摘要: Abstract Background Lung cancer leads to the largest number of cancer-related deaths worldwide and is usually accompanied with metastasis which primary cause those death correlated poor prognosis. However, mechanism lung still lack definition. Methods We compared adenocarcinoma (AD) its tissues induced by overexpression KrasG12D inactivation P53 in mouse lungs analyzing GSE40222 about differentially expressed genes (DEGs), pathways hub genes. And human AD databases are used verify conversed changes identified key gene then followed functional studies performed explore functions gene. Results 165 AD. Pathway analysis 649 GO biological processes 8 KEGG pathways, such as ECM-receptor interaction. Biological network interaction during metastasis, up-regulated COL5A1, a novel metastasis. found it's also increased advanced stage. Knockdown COL5A1 metastatic cells inhibited cell growth invasion, apoptosis. Notably, higher expression was observed patients recurrence short survive. Conclusion By metastases, we potential regulating COL5A1. The following database explores functions, holding implications target therapy providing more clues for future studies.