Methods and kits for detecting mutations

作者: Marijo Kent-First , Richard Halberg , Keith V. Wood , Jeffery Bacher

DOI:

关键词: MutagenMicrosatelliteGeneticsBiologyOrganismCellCancer cellDNAMicrosatellite instabilityLocus (genetics)

摘要: Disclosed are methods and kits for detecting mutations in DNA by comparing the size of an amplified microsatellite locus to expected size. The may used various applications, including monitoring exposure a cell or organism mutagen, evaluating mutagenicity agent, putative precancerous cancerous tumor instability.

参考文章(22)
Ariege Muallem, Marijo Kent First, Male infertility y-deletion detection battery ,(1997)
Robert S. Lahue, Richard Pelletier, Juan J. Miret, Genetic assays for trinucleotide repeat mutations in eukaryotic cells ,(2000)
Bert Vogelstein, Kenneth W. Kinzler, Albert de la Chapelle, Tumor classification as indication of hereditary non-polyposis colorectal carcinoma ,(1997)
Nikolai Lisitsyn, Michael Wigler, Cancer detection probes ,(1996)
Gary D. Bren, Stephen N. Thibodeau, Tumor-specific genomic instability as a prognostic indicator ,(1994)
Bert Vogelstein, Kenneth W. Kinzler, Albert de la Chapelle, Diagnostic method employing MSH2 protein ,(1995)
Jeffery W. Bacher, Laura Flanagan, Nadine Nassif, Detection of microsatellite instability and its use in diagnosis of tumors ,(2002)
Richard Fishel, Josef Ruschoff, Wolfgang Dietmaier, Method for the detection of microsatellite instability for tumor diagnostics ,(1998)