68Ga-DOTATATE: Significance of uptake in the tail of the pancreas in patients without lesions.

摘要: 1278 Objectives: Neuroendocrine tumors (NETs) are uncommon but with increasing incidence and prevalence. 68Ga-DOTATATE is a PET radiopharmaceutical for somatostatin receptor (SSR) detection. After reviewing multiple patients PET/CT, the authors noticed equivocal interpretations of uptake in tail pancreas. The purpose our study was to measure semi-quantitatively using SUVs pancreas compared normal liver parenchyma SSR-positive lesions. Methods: We reviewed PET/low mAs CT images 35 consecutive performed between October 4, 2017 January 23, 2018. There were 17 male 18 females ranging age from 37 80 years (mean +/- SD = 57.1 10.7). measured by two observers average values tail. Normal SUVaverage size region interest (ROI) 23.48 cm2, lesion SUVpeak ROI 0.78 SUVpeak. An ABR-certified radiologist corresponding available diagnostic CTs MRI abdomen assess presence lesions Results: indications referral PET/CT following: 1. Evidence new (n=9), restaging (n=5), NET metastases (n=11), elevated tumor markers (n=10). Twenty-four had resection or biopsy prior nine tissue acquisition after PET/CT. 3.9 +/-1.0. median 17.65 (interquartile range: 5.55, 24.35). In 31 without anatomical lesions, 3.7 1.1. no significant difference (p=0.59) five slightly above that interpreted equivocally as cancer. One these peripancreatic lymph node addition fine needle aspiration demonstrated neuroendocrine tumor. He underwent distal pancreatectomy pathologic examination revealed islet cell hyperplasia. Conclusion: observed that68Ga-DOTATATE consistent SSR-avid lesion. equal can be normal. Patients equivalent should undergo further imaging either contrast-enhanced before procedural intervention confirm pathological lesion. Figure 1: 68GA-DOTATATE 43 year-old man who presented carcinoid syndrome: A. transmission, B. Fusion image, C. PET, D. Maximum intensity projection (MIP). outside contrast 1 cm retroperitoneal at level renal vessels. A seen on MIP. transaxial image same (arrow).