Integrated sensor with electrical and optical single molecule sensitivity

摘要: An optical waveguide is constructed so as to comprise a non-solid core layer surrounded by solid-state material and nanopore or micropore in fluid communication with the core. The has an index of refraction which lower than surrounding material, light can be transmitted low loss through layer. In exemplary application, comprises sample whose transmission, absorption, and/or interference characteristics are measured. addition, perpendicular portion may included for use injecting into measuring fluorescence associated material. Most preferably, generally structured anti-resonant reflecting (ARROW), Fabry-Perot reflector adjacent layer, whereby substantially prevented from leaking out said transverse direction.