Progress in and deterrents to orthotopic liver transplantation, with special reference to survival, resistance to hyperacute rejection, and biliary duct reconstruction

摘要: There is almost no aspect of clinical organ transplantation into which Dave Hume did not breathe life. Liver was exception. It will surprise one that his contributions were important and concisely stated, although never published. He gave observations to us (T.E.S.) as personal communications throughout the years granted permission for their use in a book published 5 ago.1 They should be listed briefly. Hume performed earliest auxiliary hepatic transplantations, splenic fossa recipient whose abdomen could accommodate extra plus host liver. Undaunted, he proceeded remove total native In another trial, this time with orthotopic transplantation, described hyperacute rejection, if it valid diagnosis first only documented example complication destroying liver homograft. Finally, Hume’s recipients who had hepatoma cirrhosis lived about year postoperatively after replacement, eventually dying widespread metastases similar those we have recorded indication malignancy.1 There point saying more these experiences Hume, since, they were, really peripheral main interests. Instead, I would like discuss three aspects might introduce either new data or ideas. These concern our survival statistics, rejection livers, problem biliary duct reconstruction.